Wednesday, November 01, 2006

Health Beat: Drunk Fat Rodents Live Longer

Study On Fat Mice Could Lead To Treatments For Diabetes And Heart Disease:
Researchers have used a single compound to increase the lifespan of obese mice, and found that the drug reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets–some of which are associated with diabetes, heart disease, and other significant diseases related to obesity. The research, led by investigators at Harvard Medical School and the National Institute on Aging, is the first time that the small molecule resveratrol has been shown to offer survival benefits in a mammal. The study is reported in the November 1 advanced online edition of Nature.
“Mice are much closer evolutionarily to humans than any previous model organism treated by this molecule, which offers hope that similar impacts might be seen in humans without negative side-effects,” says co-senior author David Sinclair, HMS associate professor of pathology, and co-director of the Paul F. Glenn Labs for the Biological Mechanisms of Aging.

“After six months, resveratrol essentially prevented most of the negative effects of the high calorie diet in mice,” said Rafael de Cabo, Ph.D., the study’s other co-senior investigator from the National Institute on Aging’s Laboratory of Experimental Gerontology, Aging, Metabolism, and Nutrition Unit. Resveratrol is found in red wines and produced by a variety of plants when put under stress.

“There is a lot of work ahead that will help us better understand resveratrol’s roles and the best applications for it.”

Yeah, like isolating and separating the resveratrol from the wine. To achieve the same benefits as the mice, you would have to drink 1500 bottles of red wine a day.

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